Nearly three-quarters of all known bacterial species have never been studied in scientific literature, while just 10 species account for half of all published research, according to a new analysis published on bioRxiv.

The study of over 43,000 bacterial species found that E. coli dominates with 21% of all publications, followed by human pathogens like Staphylococcus aureus. Microbes crucial for human health and Earth’s ecosystems remain largely unexplored, University of Michigan biologist Paul Jensen reported.

A new $1-million project by non-profit Align to Innovate aims to help close this gap by studying 1,000 microbes under varying conditions.